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2017 ; 61
(4
): ä Nephropedia Template TP
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Antimicrobial Effects of Antipyretics
#MMPMID28137805
Zimmermann P
; Curtis N
Antimicrob Agents Chemother
2017[Apr]; 61
(4
): ä PMID28137805
show ga
Antipyretics are some of the most commonly used drugs. Since they are often
coadministered with antimicrobial therapy, it is important to understand the
interactions between these two classes of drugs. Our review is the first to
summarize the antimicrobial effects of antipyretic drugs and the underlying
mechanisms involved. Antipyretics can inhibit virus replication, inhibit or
promote bacterial or fungal growth, alter the expression of virulence factors,
change the surface hydrophobicity of microbes, influence biofilm production,
affect the motility, adherence, and metabolism of pathogens, interact with the
transport and release of antibiotics by leukocytes, modify the susceptibility of
bacteria to antibiotics, and induce or reduce the frequency of mutations leading
to antimicrobial resistance. While antipyretics may compromise the efficacy of
antimicrobial therapy, they can also be beneficial, for example, in the
management of biofilm-associated infections, in reducing virulence factors, in
therapy of resistant pathogens, and in inducing synergistic effects. In an era
where it is becoming increasingly difficult to find new antimicrobial drugs,
targeting virulence factors, enhancing the efficacy of antimicrobial therapy, and
reducing resistance may be important strategies.
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