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2018 ; 25
(ä): 52-54
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Anticoagulation in Behçet related intrathoracic vasculitis
#MMPMID30003020
Nokes B
; Tseng AS
; Cartin-Ceba R
; Shamoun F
; Jokerst C
; Mertz L
Respir Med Case Rep
2018[]; 25
(ä): 52-54
PMID30003020
show ga
Behçet disease is a rare multisystem condition associated with HLA-B51 positivity
that commonly afflicts individuals of Turkish or Middle Eastern descent, less
than 10% of whom have pulmonary involvement. Behçet-related pulmonary vasculitis
is an uncommon and heterogeneous group of conditions, often with associated
pulmonary artery thrombus formation. These microthrombi can result in a
misdiagnosis of acute pulmonary embolism. Anticoagulation therapy can be
difficult, as blood thinners increase the risk of pulmonary hemorrhage without
affording the same benefits as in pulmonary embolism management. We present two
cases of pulmonary vasculitis in the context of Behçet's syndrome, one in a
Native American man with associated superior vena cava syndrome and pericarditis,
with an increased risk of hemorrhagic pericardial effusion, and the other in an
African American man with acute hypoxic respiratory failure with an increased
risk of alveolar hemorrhage. We describe their management and the balancing act
surrounding anticoagulation therapy in Behcet-related pulmonary vasculitis.