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2016 ; 7
(ä): 63
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Antibody Targeting of "Steady-State" Dendritic Cells Induces Tolerance Mediated
by Regulatory T Cells
#MMPMID26941742
Mahnke K
; Ring S
; Enk AH
Front Immunol
2016[]; 7
(ä): 63
PMID26941742
show ga
Dendritic cells (DCs) are often defined as pivotal inducers of immunity, but
these proinflammatory properties only develop after stimulation or ex vivo
manipulation of DCs. Under non-inflammatory conditions in vivo, DCs are embedded
into a tissue environment and encounter a plethora of self-antigens derived from
apoptotic material. This material is transported to secondary lymphoid organs. As
DCs maintain their non-activated phenotype in a sterile tissue environment,
interaction with T cells will induce rather regulatory T cells than effector T
cells. Thus, DCs are not only inducers of immunity but are also critical for
maintenance of peripheral tolerance. Therapeutically, intervention for the
induction of long-lasting tolerance in several autoimmune conditions may
therefore be possible by manipulating DC activation and/or targeting of DCs in
their "natural" tissue environment.