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10.1021/acsomega.7b01368 http://scihub22266oqcxt.onion/10.1021/acsomega.7b01368 C6044581!6044581 !30023551     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30023551 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\30023551 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       ACS+Omega 2017 ; 2 (10 ): 7400-7409 Nephropedia Template TP {{tp|p=30023551 |t=2017. Antibiotic Resistance: Current Perspectives |pdf=|usr=}}{{30023551 }} gab.com Text Antibiotic Resistance: Current Perspectives JO: ACS Omega http://www.kidney.de/pget.php?&tw=1&pmid=30023551 #FOAvip Antibiotic resistance is one of the most serious challenges that the world is currently facing. The number of people succumbing to drug-resistant infections is increasing every day, but the rate of drug discovery has failed to match the requisite demands. Most of the currently known antibiotics target the three essential pathways of central dogma. However, bacteria have evolved multiple mechanisms to survive these antibiotics. Consequently, there is an urgent necessity to target auxiliary pathways for the discovery of new drugs. Metabolism-related and stress-associated pathways are ideal in this regard. The stringent response pathway regulated by the signaling nucleotides (p)ppGpp is an attractive target as inhibition of the pathway would in turn decrease the persistence and long-term survival of pathogenic bacteria. In this perspective, we focus on the recent design of small molecule analogues of (p)ppGpp that have yielded promising results in terms of growth and biofilm inhibition. Additionally, we discuss how targeting small RNAs and riboswitches, as well as antimicrobial peptides, would help combat drug-resistant infections in the near future. Twit Text FOAVip Antibiotic Resistance: Current Perspectives ????ACS Omega http://www.kidney.de/pget.php?&tw=1&pmid=30023551 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30023551 #FOAvip English Wikipedia <ref>{{Cite pmid|30023551 }}</ref> Antibiotic Resistance: Current Perspectives #MMPMID30023551 Petchiappan A ; Chatterji D ACS Omega 2017[Oct]; 2 (10 ): 7400-7409 PMID30023551 show ga Antibiotic resistance is one of the most serious challenges that the world is currently facing. The number of people succumbing to drug-resistant infections is increasing every day, but the rate of drug discovery has failed to match the requisite demands. Most of the currently known antibiotics target the three essential pathways of central dogma. However, bacteria have evolved multiple mechanisms to survive these antibiotics. Consequently, there is an urgent necessity to target auxiliary pathways for the discovery of new drugs. Metabolism-related and stress-associated pathways are ideal in this regard. The stringent response pathway regulated by the signaling nucleotides (p)ppGpp is an attractive target as inhibition of the pathway would in turn decrease the persistence and long-term survival of pathogenic bacteria. In this perspective, we focus on the recent design of small molecule analogues of (p)ppGpp that have yielded promising results in terms of growth and biofilm inhibition. Additionally, we discuss how targeting small RNAs and riboswitches, as well as antimicrobial peptides, would help combat drug-resistant infections in the near future. äAntibiotic Resistance: Current Perspectives (epmc).pdf DeepDyve Pubget Overpricing