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2017 ; 9
(1
): 1327308
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Antibiofilm peptides against oral biofilms
#MMPMID28748031
Wang Z
; Shen Y
; Haapasalo M
J Oral Microbiol
2017[]; 9
(1
): 1327308
PMID28748031
show ga
The oral cavity is a major entry point for bacteria and other microorganisms.
Oral biofilms are formed by mixed communities of microorganisms embedded in an
exopolysaccharide matrix. Biofilms forming on dental hard or soft tissue are the
major cause of caries and endodontic and periodontal disease. Human oral biofilms
exhibit high resistance to antimicrobial agents. Antibiofilm peptides constitute
a diverse class of host-defense molecules that act to combat invasion and
infection with biofilms. Different in vitro and in vivo biofilm models with
quantitative analysis have been established to provide predictable platforms for
the evaluation of the antibiofilm effect of oral antibiofilm peptides. These
peptides have engendered considerable interest in the past decades as potential
alternatives to traditional disinfecting agents due to their ability to target
bacterial biofilms specifically, leading to the prevention of biofilm formation
and destruction of pre-existing biofilms by Gram-positive and -negative bacterial
pathogens and fungi. At the same time, challenges associated with the application
of these antibiofilm peptides in dental practice also exist. The production of
effective, nontoxic, and stable antibiofilm peptides is desired in both academic
and industrial fields. This review focuses on the antibiofilm properties of
current synthetic peptides and their application in different areas of dentistry.
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