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2015 ; 10
(4
): 1419-1422
Nephropedia Template TP
Tomizawa M
; Shinozaki F
; Fugo K
; Motoyoshi Y
; Sugiyama T
; Yamamoto S
; Kishimoto T
; Ishige N
Exp Ther Med
2015[Oct]; 10
(4
): 1419-1422
PMID26622500
show ga
Anti-mitochondrial M2 antibody (AMA-M2) is specific to primary biliary cirrhosis
(PBC), but can also be found in certain patients with autoimmune hepatitis (AIH).
Effective methods of differentiating between PBC and AIH are required, as their
clinical course and management are different. Titers of AMA-M2 were analyzed
before and after follow-up in patients with PBC or AIH. Patients who underwent
liver biopsy and were diagnosed with either AIH (10 patients) or PBC (3 patients)
were enrolled in the study. The AMA-M2 antibody titers of these patients were
analyzed upon hospital admission. AMA-M2 reacted with the pyruvate dehydrogenase
complex-E2, branched-chain 2-oxo acid dehydrogenase complex and 2-oxoglutaric
acid dehydrogenase complex in the assay utilized for this study. The cut-off
value for AMA-M2 was 5. Six AIH patients were AMA-M2(-) and 4 were AMA-M2(+). The
titer for the AIH patients who were AMA-M2(+) was 24.8±14.8, compared with
324±174 in the patients with PBC (P=0.0138). Three AMA-M2(+) AIH patients were
followed-up after liver biopsy. The AMA-M2 levels had decreased in all 3
patients, becoming undetectable in 2 of them. In conclusion, certain patients
with AIH in this study were found to be AMA-M2(+), but the titers were
significantly lower than those in the patients with PBC. At follow-up, the AIH
patients exhibited decreased AMA-M2 titers.