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10.1242/bio.024562 http://scihub22266oqcxt.onion/10.1242/bio.024562 C5576074!5576074 !28642243     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28642243 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biol+Open 2017 ; 6 (8 ): 1130-1136 Nephropedia Template TP {{tp|p=28642243 |t=2017. Anti-inflammatory and anti-osteoarthritis effects of tectorigenin |pdf=|usr=}}{{28642243 }} gab.com Text Anti-inflammatory and anti-osteoarthritis effects of tectorigenin JO: Biol Open http://www.kidney.de/pget.php?&tw=1&pmid=28642243 #FOAvip Osteoarthritis (OA) is a common and dynamic disease of the joints, including the articular cartilage, underlying bones and synovium. In particular, OA is considered as the degeneration of the cartilage. Tectorigenin (Tec) is known to affect many biological processes; however, its effects on articular chondrocytes remain unclear. This study aimed to assess the effects of Tec on articular cartilage. In vitro, Tec inhibited the expression levels of type X collagen, cyclooxigenase-2, matrix metalloproteinase (MMP)-3 and MMP-13, but enhanced the expression of Runx1, type II collagen and aggrecan in the presence of IL-1?. Meanwhile, Tec inhibited apoptosis through the Bax/Bcl-2/caspase-3 pathway, upregulating p-Bad, downregulating the Bax/Bcl-2 ratio, and activating caspase-3 compared with IL-1? treatment only. Moreover, this process was partially regulated by NF-?B P65. In vivo, the chondroprotective effects of Tec were assessed by establishing a model of surgically induced OA. Tec-treated joints exhibited fewer osteoarthritic changes than saline-treated joints. Meanwhile, 1.5??g/kg Tec treatment produced a greater protective effect than 0.75??g/kg Tec. The Osteoarthritis Research Society International (OARSI) scoring system, employed to assess histopathological grading of the models, as well immunohistochemistry for Aggrecan Neoepitope and MMP-3, further confirmed the results. In conclusion, this study showed that Tec plays a chondroprotective role in the OA process by preventing articular cartilage degeneration and chondrocyte apoptosis via the NF-?B P65 pathway. Twit Text FOAVip Anti-inflammatory and anti-osteoarthritis effects of tectorigenin ????Biol Open http://www.kidney.de/pget.php?&tw=1&pmid=28642243 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28642243 #FOAvip English Wikipedia <ref>{{Cite pmid|28642243 }}</ref> Anti-inflammatory and anti-osteoarthritis effects of tectorigenin #MMPMID28642243 Wang CL ; Li D ; Wang CD ; Xiao F ; Zhu JF ; Shen C ; Zuo B ; Cui YM ; Wang H ; Gao Y ; Hu GL ; Zhang XL ; Chen XD Biol Open 2017[Aug]; 6 (8 ): 1130-1136 PMID28642243 show ga Osteoarthritis (OA) is a common and dynamic disease of the joints, including the articular cartilage, underlying bones and synovium. In particular, OA is considered as the degeneration of the cartilage. Tectorigenin (Tec) is known to affect many biological processes; however, its effects on articular chondrocytes remain unclear. This study aimed to assess the effects of Tec on articular cartilage. In vitro, Tec inhibited the expression levels of type X collagen, cyclooxigenase-2, matrix metalloproteinase (MMP)-3 and MMP-13, but enhanced the expression of Runx1, type II collagen and aggrecan in the presence of IL-1?. Meanwhile, Tec inhibited apoptosis through the Bax/Bcl-2/caspase-3 pathway, upregulating p-Bad, downregulating the Bax/Bcl-2 ratio, and activating caspase-3 compared with IL-1? treatment only. Moreover, this process was partially regulated by NF-?B P65. In vivo, the chondroprotective effects of Tec were assessed by establishing a model of surgically induced OA. Tec-treated joints exhibited fewer osteoarthritic changes than saline-treated joints. Meanwhile, 1.5??g/kg Tec treatment produced a greater protective effect than 0.75??g/kg Tec. The Osteoarthritis Research Society International (OARSI) scoring system, employed to assess histopathological grading of the models, as well immunohistochemistry for Aggrecan Neoepitope and MMP-3, further confirmed the results. In conclusion, this study showed that Tec plays a chondroprotective role in the OA process by preventing articular cartilage degeneration and chondrocyte apoptosis via the NF-?B P65 pathway. äAnti-inflammatory and anti-osteoarthritis effects of tectorigenin (epmc).pdf DeepDyve Pubget Overpricing