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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Microsc+Ultrastruct
2018 ; 6
(1
): 1-10
Nephropedia Template TP
J Microsc Ultrastruct
2018[Jan]; 6
(1
): 1-10
PMID30023261
show ga
Increasing extent of pathogenic resistance to drugs has encouraged the seeking
for new anti-virulence drugs. Many pharmacological and pharmacognostical
researches are performed to identify new drugs or discover new structures for the
development of novel therapeutic agents in the antibiotic treatments. Although
many phytochemicals show prominent antimicrobial activity, their power lies in
their anti-virulence properties. Quorum sensing (QS) is a bacterial intercellular
communication mechanism, which depends on bacterial cell population density and
controls the pathogenesis of many organisms by regulating gene expression,
including virulence determinants. QS has become an attractive target for the
development of novel anti-infective agents that do not rely on the use of
antibiotics. Anti-QS compounds are known to have the ability to prohibit
bacterial pathogenicity. Medicinal plants offer an attractive repertoire of
phytochemicals with novel microbial disease-controlling potential, due to the
spectrum of secondary metabolites present in extracts, which include phenolics,
quinones, flavonoids, alkaloids, terpenoids, and polyacetylenes. They have
recently received considerable attention as a new source of safe and effective QS
inhibitory substances. The objective of this review is to give a brief account of
the research reports on the plants and natural compounds with anti-QS potential.
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