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10.1097/MD.0000000000005280 http://scihub22266oqcxt.onion/10.1097/MD.0000000000005280 C5591145!5591145 !27858897     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27858897 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27858897 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Medicine+(Baltimore) 2016 ; 95 (44 ): e5280 Nephropedia Template TP {{tp|p=27858897 |t=2016. Anti-HMGCR antibodies in systemic sclerosis |pdf=|usr=}}{{27858897 }} gab.com Text Anti-HMGCR antibodies in systemic sclerosis JO: Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=27858897 #FOAvip The objective of this study was to investigate the frequency of autoantibodies to hydroxymethylglutaryl coenzyme A reductase (HMGCR) in systemic sclerosis (SSc) and associations with inflammatory myositis and statin exposure.This was a cross-sectional, multicenter study of 306 subjects from the Canadian Scleroderma Research Group cohort who had complete data on statin exposure and serology for anti-HMGCR antibodies assayed by an addressable laser bead immunoassay (ALBIA). Descriptive statistics were used to summarize the baseline characteristics of the patients and to compare subjects with and without anti-HMGCR antibodies.Four (1.3%) subjects had anti-HMGCR antibodies. None of the subjects with anti-HMGCR antibodies titers had a history of an inflammatory myositis or overlap with polymyositis/dermatomyositis, compared to 8.6% and 2.0% of those without anti-HMGCR antibodies, respectively. In addition, none of the subjects with anti-HMGCR antibodies had past or current exposure to statins compared to 12% of those with negative titers.Anti-HMGCR antibodies are rare in SSc and are not associated with inflammatory myopathy or statin exposure. Larger studies will be required to confirm these preliminary observations. Nevertheless, we conclude that anti-HMGCR antibodies are unlikely to play a major role in inflammatory myopathy in SSc and anti-HMGCR antibodies can be present in subjects without exposure to statins. Twit Text FOAVip Anti-HMGCR antibodies in systemic sclerosis ????Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=27858897 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27858897 #FOAvip English Wikipedia <ref>{{Cite pmid|27858897 }}</ref> Anti-HMGCR antibodies in systemic sclerosis #MMPMID27858897 Hudson M ; Luck Y ; Stephenson M ; Choi MY ; Wang M ; Baron M ; Fritzler MJ Medicine (Baltimore) 2016[Nov]; 95 (44 ): e5280 PMID27858897 show ga The objective of this study was to investigate the frequency of autoantibodies to hydroxymethylglutaryl coenzyme A reductase (HMGCR) in systemic sclerosis (SSc) and associations with inflammatory myositis and statin exposure.This was a cross-sectional, multicenter study of 306 subjects from the Canadian Scleroderma Research Group cohort who had complete data on statin exposure and serology for anti-HMGCR antibodies assayed by an addressable laser bead immunoassay (ALBIA). Descriptive statistics were used to summarize the baseline characteristics of the patients and to compare subjects with and without anti-HMGCR antibodies.Four (1.3%) subjects had anti-HMGCR antibodies. None of the subjects with anti-HMGCR antibodies titers had a history of an inflammatory myositis or overlap with polymyositis/dermatomyositis, compared to 8.6% and 2.0% of those without anti-HMGCR antibodies, respectively. In addition, none of the subjects with anti-HMGCR antibodies had past or current exposure to statins compared to 12% of those with negative titers.Anti-HMGCR antibodies are rare in SSc and are not associated with inflammatory myopathy or statin exposure. Larger studies will be required to confirm these preliminary observations. Nevertheless, we conclude that anti-HMGCR antibodies are unlikely to play a major role in inflammatory myopathy in SSc and anti-HMGCR antibodies can be present in subjects without exposure to statins. |Autoantibodies/*blood [MESH] |Cross-Sectional Studies [MESH] |Female [MESH] |Humans [MESH] |Hydroxymethylglutaryl CoA Reductases/*immunology [MESH] |Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use [MESH] |Male [MESH] |Middle Aged [MESH] |Myositis/blood/complications [MESH]Anti-HMGCR antibodies in systemic sclerosis (epmc).pdf DeepDyve Pubget Overpricing