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2015 ; 11
(6
): e1004160
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Antenna Mechanism of Length Control of Actin Cables
#MMPMID26107518
Mohapatra L
; Goode BL
; Kondev J
PLoS Comput Biol
2015[Jun]; 11
(6
): e1004160
PMID26107518
show ga
Actin cables are linear cytoskeletal structures that serve as tracks for
myosin-based intracellular transport of vesicles and organelles in both yeast and
mammalian cells. In a yeast cell undergoing budding, cables are in constant
dynamic turnover yet some cables grow from the bud neck toward the back of the
mother cell until their length roughly equals the diameter of the mother cell.
This raises the question: how is the length of these cables controlled? Here we
describe a novel molecular mechanism for cable length control inspired by recent
experimental observations in cells. This "antenna mechanism" involves three key
proteins: formins, which polymerize actin, Smy1 proteins, which bind formins and
inhibit actin polymerization, and myosin motors, which deliver Smy1 to formins,
leading to a length-dependent actin polymerization rate. We compute the
probability distribution of cable lengths as a function of several experimentally
tuneable parameters such as the formin-binding affinity of Smy1 and the
concentration of myosin motors delivering Smy1. These results provide testable
predictions of the antenna mechanism of actin-cable length control.
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