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2014 ; 10
(7
): 2118-22
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English Wikipedia
Antenatal immunization
#MMPMID25424828
Jones C
; Heath P
Hum Vaccin Immunother
2014[]; 10
(7
): 2118-22
PMID25424828
show ga
Pregnancy and early infancy are periods of relative immune suppression and
increased vulnerability to infection. In these circumstances infections are
associated with high morbidity and mortality. In particular, infants have high
rates of invasive disease, higher than at any other stage of life with rates of
100 per 100?000 population. The concept of maternal vaccination is that maternal
levels of pathogen-specific antibody are boosted and provide protection to the
infant until the infant is able to mount an effective immune response to
immunization. However, an important concern for women and healthcare providers is
the safety of receiving vaccines during pregnancy. There are challenges
associated with assessing safety in pregnant women. This review discusses the
rationale for maternal vaccination, the concepts and mechanisms used. An
assessment is made of the safety of vaccination during pregnancy, and the
challenges associated with this are considered. In general terms, it is
considered that the risk from disease far outweighs the small risk associated
with vaccination during pregnancy and that they offer a new platform for
preventing significant and serious infections in mothers and young infants.
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