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10.1038/s41598-017-15557-5 http://scihub22266oqcxt.onion/10.1038/s41598-017-15557-5 C5684314!5684314 !29133828     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29133828 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29133828 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 15383 Nephropedia Template TP {{tp|p=29133828 |t=2017. Animal multicellularity and polarity without Wnt signaling |pdf=|usr=}}{{29133828 }} gab.com Text Animal multicellularity and polarity without Wnt signaling JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29133828 #FOAvip Acquisition of multicellularity is a central event in the evolution of Eukaryota. Strikingly, animal multicellularity coincides with the emergence of three intercellular communication pathways - Notch, TGF-? and Wnt - all considered as hallmarks of metazoan development. By investigating Oopsacas minuta and Aphrocallistes vastus, we show here that the emergence of a syncytium and plugged junctions in glass sponges coincides with the loss of essential components of the Wnt signaling (i.e. Wntless, Wnt ligands and Disheveled), whereas core components of the TGF-? and Notch modules appear unaffected. This suggests that Wnt signaling is not essential for cell differentiation, polarity and morphogenesis in glass sponges. Beyond providing a comparative study of key developmental toolkits, we define here the first case of a metazoan phylum that maintained a level of complexity similar to its relatives despite molecular degeneration of Wnt pathways. Twit Text FOAVip Animal multicellularity and polarity without Wnt signaling ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29133828 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29133828 #FOAvip English Wikipedia <ref>{{Cite pmid|29133828 }}</ref> Animal multicellularity and polarity without Wnt signaling #MMPMID29133828 Schenkelaars Q ; Pratlong M ; Kodjabachian L ; Fierro-Constain L ; Vacelet J ; Le Bivic A ; Renard E ; Borchiellini C Sci Rep 2017[Nov]; 7 (1 ): 15383 PMID29133828 show ga Acquisition of multicellularity is a central event in the evolution of Eukaryota. Strikingly, animal multicellularity coincides with the emergence of three intercellular communication pathways - Notch, TGF-? and Wnt - all considered as hallmarks of metazoan development. By investigating Oopsacas minuta and Aphrocallistes vastus, we show here that the emergence of a syncytium and plugged junctions in glass sponges coincides with the loss of essential components of the Wnt signaling (i.e. Wntless, Wnt ligands and Disheveled), whereas core components of the TGF-? and Notch modules appear unaffected. This suggests that Wnt signaling is not essential for cell differentiation, polarity and morphogenesis in glass sponges. Beyond providing a comparative study of key developmental toolkits, we define here the first case of a metazoan phylum that maintained a level of complexity similar to its relatives despite molecular degeneration of Wnt pathways. |*Models, Biological [MESH] |*Porifera/cytology/physiology [MESH] |*Wnt Signaling Pathway [MESH] |Animals [MESH] |Morphogenesis/*physiology [MESH] |Transforming Growth Factor beta/*metabolism [MESH]Animal multicellularity and polarity without Wnt signaling (epmc).pdf DeepDyve Pubget Overpricing