Animal models of tuberculosis: Guinea pigs
#MMPMID25524720
Clark S
; Hall Y
; Williams A
Cold Spring Harb Perspect Med
2014[Dec]; 5
(5
): a018572
PMID25524720
show ga
The progression of the disease that follows infection of guinea pigs with
Mycobacterium tuberculosis displays many features of human tuberculosis (TB), and
the guinea pig model of TB has been used for more than 100 years as a research
tool to understand and describe disease mechanisms. Changes in the bacterial
burden and pathology following infection can be readily monitored and used to
evaluate the impact of TB interventions. Demonstration of the protective efficacy
of vaccines in the low-dose aerosol guinea pig model is an important component of
the preclinical data package for novel vaccines in development, and there is a
continual need to improve the model to facilitate progression of vaccines to the
clinic. Development of better tools with which to dissect the immune responses of
guinea pigs is a focus of current research.
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