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2011 ; 2
(3
): 189-201
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Animal models for the atherosclerosis research: a review
#MMPMID21468891
Xiangdong L
; Yuanwu L
; Hua Z
; Liming R
; Qiuyan L
; Ning L
Protein Cell
2011[Mar]; 2
(3
): 189-201
PMID21468891
show ga
Atherosclerosis is a leading cause of death worldwide, and its mechanisms are
still unclear. However, various animal models have significantly advanced our
understanding of the mechanisms involved in atherosclerosis and have allowed the
evaluation of therapeutic options. The aim of this paper is to review those
animal models (i.e., rabbits, mice, rats, guinea pigs, hamsters, avian,
carnivores, swine, and, non-human primates) that have been used to study
atherosclerosis. Though there is no single perfect animal model that completely
replicates the stages of human atherosclerosis, cholesterol feeding and
mechanical endothelial injury are two common features shared by most models of
atherosclerosis. Further, with the development of genetically modified animals,
these models are significantly broadening our understanding of the pathogenesis
of atherosclerosis.