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2015 ; 52
(5
): 827-41
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Animal Models of Bone Metastasis
#MMPMID26021553
Simmons JK
; Hildreth BE 3rd
; Supsavhad W
; Elshafae SM
; Hassan BB
; Dirksen WP
; Toribio RE
; Rosol TJ
Vet Pathol
2015[Sep]; 52
(5
): 827-41
PMID26021553
show ga
Bone is one of the most common sites of cancer metastasis in humans and is a
significant source of morbidity and mortality. Bone metastases are considered
incurable and result in pain, pathologic fracture, and decreased quality of life.
Animal models of skeletal metastases are essential to improve the understanding
of the molecular pathways of cancer metastasis and growth in bone and to develop
new therapies to inhibit and prevent bone metastases. The ideal animal model
should be clinically relevant, reproducible, and representative of human disease.
Currently, an ideal model does not exist; however, understanding the strengths
and weaknesses of the available models will lead to proper study design and
successful cancer research. This review provides an overview of the current in
vivo animal models used in the study of skeletal metastases or local tumor
invasion into bone and focuses on mammary and prostate cancer, lymphoma, multiple
myeloma, head and neck squamous cell carcinoma, and miscellaneous tumors that
metastasize to bone.
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