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2015 ; 2015
(ä): 528757
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Animal Models in Cardiovascular Research: Hypertension and Atherosclerosis
#MMPMID26064920
Leong XF
; Ng CY
; Jaarin K
Biomed Res Int
2015[]; 2015
(ä): 528757
PMID26064920
show ga
Hypertension and atherosclerosis are among the most common causes of mortality in
both developed and developing countries. Experimental animal models of
hypertension and atherosclerosis have become a valuable tool for providing
information on etiology, pathophysiology, and complications of the disease and on
the efficacy and mechanism of action of various drugs and compounds used in
treatment. An animal model has been developed to study hypertension and
atherosclerosis for several reasons. Compared to human models, an animal model is
easily manageable, as compounding effects of dietary and environmental factors
can be controlled. Blood vessels and cardiac tissue samples can be taken for
detailed experimental and biomolecular examination. Choice of animal model is
often determined by the research aim, as well as financial and technical factors.
A thorough understanding of the animal models used and complete analysis must be
validated so that the data can be extrapolated to humans. In conclusion, animal
models for hypertension and atherosclerosis are invaluable in improving our
understanding of cardiovascular disease and developing new pharmacological
therapies.