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10.1007/s40473-015-0044-3

http://scihub22266oqcxt.onion/10.1007/s40473-015-0044-3
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suck abstract from ncbi


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pmid26525751
      Curr+Behav+Neurosci+Rep 2015 ; 2 (3 ): 146-153
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  • Anhedonia and the brain reward circuitry in depression #MMPMID26525751
  • Heshmati M ; Russo SJ
  • Curr Behav Neurosci Rep 2015[Sep]; 2 (3 ): 146-153 PMID26525751 show ga
  • Anhedonia, or the loss of pleasure in previously rewarding stimuli, is a core symptom of major depressive disorder that may reflect an underlying dysregulation in reward processing. The mesolimbic dopamine circuit, also known as the brain's reward circuit, is integral to processing the rewarding salience of stimuli to guide actions. Manifestation of anhedonia and associated depression symptoms like feelings of sadness, changes in appetite, and psychomotor effects, may reflect changes in the brain reward circuitry as a common underlying disease process. This review will synthesize the recent literature from human and rodent studies providing a circuit-level framework for understanding anhedonia in depression, with emphasis on the nucleus accumbens.
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