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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Behav+Neurosci+Rep
2015 ; 2
(3
): 146-153
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Anhedonia and the brain reward circuitry in depression
#MMPMID26525751
Heshmati M
; Russo SJ
Curr Behav Neurosci Rep
2015[Sep]; 2
(3
): 146-153
PMID26525751
show ga
Anhedonia, or the loss of pleasure in previously rewarding stimuli, is a core
symptom of major depressive disorder that may reflect an underlying dysregulation
in reward processing. The mesolimbic dopamine circuit, also known as the brain's
reward circuit, is integral to processing the rewarding salience of stimuli to
guide actions. Manifestation of anhedonia and associated depression symptoms like
feelings of sadness, changes in appetite, and psychomotor effects, may reflect
changes in the brain reward circuitry as a common underlying disease process.
This review will synthesize the recent literature from human and rodent studies
providing a circuit-level framework for understanding anhedonia in depression,
with emphasis on the nucleus accumbens.