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2017 ; 12
(4
): e0176198
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Angiopoietin-like-4 and minimal change disease
#MMPMID28441404
Cara-Fuentes G
; Segarra A
; Silva-Sanchez C
; Wang H
; Lanaspa MA
; Johnson RJ
; Garin EH
PLoS One
2017[]; 12
(4
): e0176198
PMID28441404
show ga
BACKGROUND: Minimal Change Disease (MCD) is the most common type of nephrotic
syndrome in children. Angiopoietin-like-4 (Angplt4) has been proposed as mediator
of proteinuria in MCD. The aim of this study was to evaluate the role of Angptl4
as a biomarker in MCD. METHODS: Patients with biopsy-proven primary MCD, focal
segmental glomerulosclerosis, membranous nephropathy (60, 52 and 52 respectively)
and 18 control subjects had urinary and serum Angptl4 measured by Elisa. Frozen
kidney tissue sections were stained for Angptl4. RESULTS: Angptl4 was not
identified in glomeruli of MCD patients in relapse. Urinary Angptl4 levels were
elevated in MCD in relapse as well as in patients with massive proteinuria due to
other glomerular diseases. CONCLUSION: Neither serum nor urine Angptl4 appear to
be good biomarkers in MCD. Elevated urinary Angptl4 n glomerular disease appears
to reflect the degree of proteinuria rather than any specific disease.
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