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2008 ; 7
(2
): 91-103
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Angiogenesis in the human corpus luteum
#MMPMID29699289
Sugino N
; Matsuoka A
; Taniguchi K
; Tamura H
Reprod Med Biol
2008[Jun]; 7
(2
): 91-103
PMID29699289
show ga
Angiogenesis is important for the formation and development of the corpus luteum
and for maintenance of luteal function. Blood vessel regression is an important
physiological phenomenon in the corpus luteum, which is associated with tissue
involution during structural luteolysis. Angiogenesis actively occurs during the
early luteal phase and is completed by the mid-luteal phase. Perivascular cells
(pericytes) increase in number from the early luteal phase to the mid-luteal
phase, suggesting that blood vessels are gradually stabilized until the
mid-luteal phase. In the corpus luteum undergoing luteolysis, blood vessels and
pericytes decrease in number, which is related to structural involution. In the
corpus luteum of early pregnancy, the number of blood vessels with pericytes
increases, suggesting that angiogenesis occurs again, accompanied by blood vessel
stabilization. These changes in vasculature of the corpus luteum are regulated by
the collaboration with vascular endothelial growth factor, which is involved in
proliferation of vascular endothelial cells, and angiopoietins, which are
involved in stabilization of blood vessels. This review focuses on angiogenesis,
blood vessel stabilization and blood vessel regression during the divergent
phases of luteal formation, luteal regression and luteal rescue by pregnancy.
(Reprod Med Biol 2008; 7: 91-103).