Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25848465
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25848465
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 World+J+Hepatol
2015 ; 7
(3
): 377-91
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Angiogenesis and liver fibrosis
#MMPMID25848465
Elpek GÖ
World J Hepatol
2015[Mar]; 7
(3
): 377-91
PMID25848465
show ga
Recent data indicate that hepatic angiogenesis, regardless of the etiology, takes
place in chronic liver diseases (CLDs) that are characterized by inflammation and
progressive fibrosis. Because anti-angiogenic therapy has been found to be
efficient in the prevention of fibrosis in experimental models of CLDs, it is
suggested that blocking angiogenesis could be a promising therapeutic option in
patients with advanced fibrosis. Consequently, efforts are being directed to
revealing the mechanisms involved in angiogenesis during the progression of liver
fibrosis. Literature evidences indicate that hepatic angiogenesis and fibrosis
are closely related in both clinical and experimental conditions. Hypoxia is a
major inducer of angiogenesis together with inflammation and hepatic stellate
cells. These profibrogenic cells stand at the intersection between inflammation,
angiogenesis and fibrosis and play also a pivotal role in angiogenesis. This
review mainly focuses to give a clear view on the relevant features that
communicate angiogenesis with progression of fibrosis in CLDs towards the-end
point of cirrhosis that may be translated into future therapies. The pathogenesis
of hepatic angiogenesis associated with portal hypertension, viral hepatitis,
non-alcoholic fatty liver disease and alcoholic liver disease are also discussed
to emphasize the various mechanisms involved in angiogenesis during liver
fibrogenesis.