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10.3390/ijms17040497 http://scihub22266oqcxt.onion/10.3390/ijms17040497 C4848953!4848953 !27049383     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27049383 &cmd=llinks): Failed to open stream: HTTP request failed! 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Aneurysmal Subarachnoid Hemorrhage and Neuroinflammation: A Comprehensive Review |pdf=|usr=}}{{27049383 }} gab.com Text Aneurysmal Subarachnoid Hemorrhage and Neuroinflammation: A Comprehensive Review JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=27049383 #FOAvip Aneurysmal subarachnoid hemorrhage (SAH) can lead to devastating outcomes including vasospasm, cognitive decline, and even death. Currently, treatment options are limited for this potentially life threatening injury. Recent evidence suggests that neuroinflammation plays a critical role in injury expansion and brain damage. Red blood cell breakdown products can lead to the release of inflammatory cytokines that trigger vasospasm and tissue injury. Preclinical models have been used successfully to improve understanding about neuroinflammation following aneurysmal rupture. The focus of this review is to provide an overview of how neuroinflammation relates to secondary outcomes such as vasospasm after aneurysmal rupture and to critically discuss pharmaceutical agents that warrant further investigation for the treatment of subarachnoid hemorrhage. We provide a concise overview of the neuroinflammatory pathways that are upregulated following aneurysmal rupture and how these pathways correlate to long-term outcomes. Treatment of aneurysm rupture is limited and few pharmaceutical drugs are available. Through improved understanding of biochemical mechanisms of injury, novel treatment solutions are being developed that target neuroinflammation. In the final sections of this review, we highlight a few of these novel treatment approaches and emphasize why targeting neuroinflammation following aneurysmal subarachnoid hemorrhage may improve patient care. We encourage ongoing research into the pathophysiology of aneurysmal subarachnoid hemorrhage, especially in regards to neuroinflammatory cascades and the translation to randomized clinical trials. Twit Text FOAVip Aneurysmal Subarachnoid Hemorrhage and Neuroinflammation: A Comprehensive Review ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=27049383 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27049383 #FOAvip English Wikipedia <ref>{{Cite pmid|27049383 }}</ref> Aneurysmal Subarachnoid Hemorrhage and Neuroinflammation: A Comprehensive Review #MMPMID27049383 Lucke-Wold BP ; Logsdon AF ; Manoranjan B ; Turner RC ; McConnell E ; Vates GE ; Huber JD ; Rosen CL ; Simard JM Int J Mol Sci 2016[Apr]; 17 (4 ): 497 PMID27049383 show ga Aneurysmal subarachnoid hemorrhage (SAH) can lead to devastating outcomes including vasospasm, cognitive decline, and even death. Currently, treatment options are limited for this potentially life threatening injury. Recent evidence suggests that neuroinflammation plays a critical role in injury expansion and brain damage. Red blood cell breakdown products can lead to the release of inflammatory cytokines that trigger vasospasm and tissue injury. Preclinical models have been used successfully to improve understanding about neuroinflammation following aneurysmal rupture. The focus of this review is to provide an overview of how neuroinflammation relates to secondary outcomes such as vasospasm after aneurysmal rupture and to critically discuss pharmaceutical agents that warrant further investigation for the treatment of subarachnoid hemorrhage. We provide a concise overview of the neuroinflammatory pathways that are upregulated following aneurysmal rupture and how these pathways correlate to long-term outcomes. Treatment of aneurysm rupture is limited and few pharmaceutical drugs are available. Through improved understanding of biochemical mechanisms of injury, novel treatment solutions are being developed that target neuroinflammation. In the final sections of this review, we highlight a few of these novel treatment approaches and emphasize why targeting neuroinflammation following aneurysmal subarachnoid hemorrhage may improve patient care. We encourage ongoing research into the pathophysiology of aneurysmal subarachnoid hemorrhage, especially in regards to neuroinflammatory cascades and the translation to randomized clinical trials. |Animals [MESH] |Brain/blood supply/immunology/*pathology [MESH] |Cytokines/analysis/immunology [MESH] |Humans [MESH] |Inflammation/*complications/immunology/pathology [MESH] |Peptide Hydrolases/analysis/immunology [MESH] |Subarachnoid Hemorrhage/*complications/immunology/*pathology/therapy [MESH]Aneurysmal Subarachnoid Hemorrhage and Neuroinflammation: A Comprehens(epmc).pdf DeepDyve Pubget Overpricing