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10.1038/nm.3814 http://scihub22266oqcxt.onion/10.1038/nm.3814 C4452951!4452951 !25742458     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25742458 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Med 2015 ; 21 (3 ): 221-30 Nephropedia Template TP {{tp|p=25742458 |t=2015. Anemia: progress in molecular mechanisms and therapies |pdf=|usr=}}{{25742458 }} gab.com Text Anemia: progress in molecular mechanisms and therapies JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=25742458 #FOAvip Anemia is a major source of morbidity and mortality worldwide. Here we review recent insights into how red blood cells (RBCs) are produced, the pathogenic mechanisms underlying various forms of anemia, and novel therapies derived from these findings. It is likely that these new insights, mainly arising from basic scientific studies, will contribute immensely to both the understanding of frequently debilitating forms of anemia and the ability to treat affected patients. Major worldwide diseases that are likely to benefit from new advances include the hemoglobinopathies (?-thalassemia and sickle cell disease); rare genetic disorders of RBC production; and anemias associated with chronic kidney disease, inflammation, and cancer. Promising new approaches to treatment include drugs that target recently defined pathways in RBC production, iron metabolism, and fetal globin-family gene expression, as well as gene therapies that use improved viral vectors and newly developed genome editing technologies. Twit Text FOAVip Anemia: progress in molecular mechanisms and therapies ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=25742458 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25742458 #FOAvip English Wikipedia <ref>{{Cite pmid|25742458 }}</ref> Anemia: progress in molecular mechanisms and therapies #MMPMID25742458 Sankaran VG ; Weiss MJ Nat Med 2015[Mar]; 21 (3 ): 221-30 PMID25742458 show ga Anemia is a major source of morbidity and mortality worldwide. Here we review recent insights into how red blood cells (RBCs) are produced, the pathogenic mechanisms underlying various forms of anemia, and novel therapies derived from these findings. It is likely that these new insights, mainly arising from basic scientific studies, will contribute immensely to both the understanding of frequently debilitating forms of anemia and the ability to treat affected patients. Major worldwide diseases that are likely to benefit from new advances include the hemoglobinopathies (?-thalassemia and sickle cell disease); rare genetic disorders of RBC production; and anemias associated with chronic kidney disease, inflammation, and cancer. Promising new approaches to treatment include drugs that target recently defined pathways in RBC production, iron metabolism, and fetal globin-family gene expression, as well as gene therapies that use improved viral vectors and newly developed genome editing technologies. |*Genetic Therapy [MESH] |Anemia/etiology/*therapy [MESH] |Fetal Hemoglobin [MESH] |Hematinics/*therapeutic use [MESH] |Hemoglobinopathies/complications/*therapy [MESH] |Humans [MESH] |Inflammation/complications [MESH] |Neoplasms/complications [MESH]Anemia: progress in molecular mechanisms and therapies (epmc).pdf DeepDyve Pubget Overpricing