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2017 ; 101
(2
): 285-296
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Anemia of Inflammation: A Review
#MMPMID28189171
Fraenkel PG
Med Clin North Am
2017[Mar]; 101
(2
): 285-296
PMID28189171
show ga
Impaired iron homeostasis and the suppressive effects of proinflammatory
cytokines on erythropoiesis, together with alterations of the erythrocyte
membrane that impair its survival, cause anemia of inflammation. Recent
epidemiologic studies have connected inflammatory anemia with critical illness,
obesity, aging, kidney failure, cancer, chronic infection, and autoimmune
disease. The proinflammatory cytokine, interleukin-6, the iron regulatory
hormone, hepcidin, and the iron exporter, ferroportin, interact to cause iron
sequestration in the setting of inflammation. Although severe anemia is
associated with adverse outcomes in critical illness, experimental models suggest
that iron sequestration is part of a natural defense against pathogens.