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2018 ; 9
(ä): 794
Nephropedia Template TP
Front Immunol
2018[]; 9
(ä): 794
PMID29755457
show ga
In addition to determining biological sex, sex hormones are known to influence
health and disease via regulation of immune cell activities and modulation of
target-organ susceptibility to immune-mediated damage. Systemic autoimmune
disorders, such as systemic lupus erythematosus, rheumatoid arthritis, and
multiple sclerosis are more prevalent in females, while cancer shows the opposite
pattern. Sex hormones have been repeatedly suggested to play a part in these
biases. In this review, we will discuss how androgens and the expression of
functional androgen receptor affect immune cells and how this may dampen or alter
immune response(s) and affect autoimmune disease incidences and progression.