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2015 ; 77-78
(ä): 164-71
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Analysis of intracellular PTEN signaling and secretion
#MMPMID25462559
Hodakoski C
; Fine B
; Hopkins B
; Parsons R
Methods
2015[May]; 77-78
(ä): 164-71
PMID25462559
show ga
The tumor suppressor PTEN dephosphorylates PIP3 to inhibit PI3K signaling in
cells. Altering PTEN intracellular signaling can therefore significantly affect
cell behavior. Two novel mechanisms of PTEN regulation including the secretion
and entry of the translational variant PTEN-L, and enzymatic inhibition by the
interacting protein P-REX2, have been shown to modulate PI3K signaling, cellular
proliferation and survival, and glucose metabolism. Here, we review the methods
used to identify and validate the existence of both PTEN-L and the P-REX2-PTEN
complex, to determine their effects on PTEN phosphatase activity, and to examine
their role in cellular physiology.