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2016 ; 11
(4
): 2913-2918
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Analysis of PI3K pathway components in human cancers
#MMPMID27073576
Daragmeh J
; Barriah W
; Saad B
; Zaid H
Oncol Lett
2016[Apr]; 11
(4
): 2913-2918
PMID27073576
show ga
Recent advances in genomics, proteomics, cell biology and biochemistry of tumors
have revealed new pathways that are aberrantly activated in numerous cancer
types. However, the enormous amount of data available in this field may mislead
scientists in focused research. As cancer cell growth and progression is often
dependent upon the phosphoinositide 3-kinase (PI3K)/AKT pathway, there has been
extensive research into the proteins implicated in the PI3K pathway. Using data
available in the Human Protein Atlas database, the current study investigated the
expression of 25 key proteins that are known to be involved with PI3K pathway
activation in a distinct group of 20 cancer types. These proteins are AKTIP,
ARP1, BAD, GSK3A, GSK3B, MERTK-1, PIK3CA, PRR5, PSTPIP2, PTEN, FOX1, RHEB,
RPS6KB1, TSC1, TP53, BCL2, CCND1, WFIKKN2, CREBBP, caspase-9, PTK2, EGFR, FAS,
CDKN1A and XIAP. The analysis revealed pronounced expression of specific proteins
in distinct cancer tissues, which may have the potential to serve as targets for
treatments and provide insights into the molecular basis of cancer.