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2010 ; 23
(3
): 266-74
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An update on the blood vessel in migraine
#MMPMID20216215
Brennan KC
; Charles A
Curr Opin Neurol
2010[Jun]; 23
(3
): 266-74
PMID20216215
show ga
PURPOSE OF REVIEW: The cranial blood vessel is considered an integral player in
the pathophysiology of migraine, but its perceived role has been subject to much
discussion and controversy over the years. We will discuss the evolution in our
scientific understanding of cranial blood vessels (primarily arteries) in
migraine. RECENT FINDINGS: Recent developments have clarified the role of cranial
blood vessels in the trigemino-vascular system and in cortical spreading
depression. An underlying theme is the intimate relation between vascular
activity and neural function, and we will emphasize the various roles of the
blood vessel that go beyond delivering blood. We conclude that migraine cannot be
understood, either from a research or clinical point of view, without an
understanding of the vascular derangements that accompany it. SUMMARY: Migraine
is accompanied by significant derangements in vascular function that may
represent important targets for investigation and treatment.
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