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2020 ; 86
(ä): 106760
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English Wikipedia
An update on antiviral antibody-based biopharmaceuticals
#MMPMID32645633
Ahangarzadeh S
; Payandeh Z
; Arezumand R
; Shahzamani K
; Yarian F
; Alibakhshi A
Int Immunopharmacol
2020[Sep]; 86
(ä): 106760
PMID32645633
show ga
Due to the vastness of the science virology, it is no longer an offshoot solely
of the microbiology. Viruses have become as the causative agents of major
epidemics throughout history. Many therapeutic strategies have been used for
these microorganisms, and in this way the recognizing of potential targets of
viruses is of particular importance for success. For decades, antibodies and
antibody fragments have occupied a significant body of the treatment approaches
against infectious diseases. Because of their high affinity, they can be designed
and engineered against a variety of purposes, mainly since antibody fragments
such as scFv, nanobody, diabody, and bispecific antibody have emerged owing to
their small size and interesting properties. In this review, we have discussed
the antibody discovery and molecular and biological design of antibody fragments
as inspiring therapeutic and diagnostic agents against viral targets.
|Animals
[MESH]
|Antibodies, Bispecific/immunology/therapeutic use
[MESH]
|Antibodies, Monoclonal/immunology/therapeutic use
[MESH]
|Antibodies, Viral/immunology/*therapeutic use
[MESH]
|Betacoronavirus/*immunology
[MESH]
|Biological Products/immunology/*therapeutic use
[MESH]