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10.1002/dvdy.24416 http://scihub22266oqcxt.onion/10.1002/dvdy.24416 C4912863!4912863 !27153394     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27153394 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Dev+Dyn 2016 ; 245 (7 ): 718-26 Nephropedia Template TP {{tp|p=27153394 |t=2016. An enduring role for quiescent stem cells |pdf=|usr=}}{{27153394 }} gab.com Text An enduring role for quiescent stem cells JO: Dev Dyn http://www.kidney.de/pget.php?&tw=1&pmid=27153394 #FOAvip The intestine's ability to recover from catastrophic injury requires quiescent intestinal stem cells (q-ISCs). While rapidly cycling (Lgr5+) crypt base columnar (CBC) ISCs normally maintain the intestine, they are highly sensitive to pathological injuries (irradiation, inflammation) and must be restored by q-ISCs to sustain intestinal homeostasis. Despite clear relevance to human health, virtually nothing is known regarding the factors that regulate q-ISCs. A comprehensive understanding of these mechanisms would likely lead to targeted new therapies with profound therapeutic implications for patients with gastrointestinal conditions. We briefly review the current state of the literature, highlighting homeostatic mechanisms important for q-ISC regulation, listing key questions in the field, and offer strategies to address them. Developmental Dynamics 245:718-726, 2016. © 2016 Wiley Periodicals, Inc. Twit Text FOAVip An enduring role for quiescent stem cells ????Dev Dyn http://www.kidney.de/pget.php?&tw=1&pmid=27153394 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27153394 #FOAvip English Wikipedia <ref>{{Cite pmid|27153394 }}</ref> An enduring role for quiescent stem cells #MMPMID27153394 Richmond CA ; Shah MS ; Carlone DL ; Breault DT Dev Dyn 2016[Jul]; 245 (7 ): 718-26 PMID27153394 show ga The intestine's ability to recover from catastrophic injury requires quiescent intestinal stem cells (q-ISCs). While rapidly cycling (Lgr5+) crypt base columnar (CBC) ISCs normally maintain the intestine, they are highly sensitive to pathological injuries (irradiation, inflammation) and must be restored by q-ISCs to sustain intestinal homeostasis. Despite clear relevance to human health, virtually nothing is known regarding the factors that regulate q-ISCs. A comprehensive understanding of these mechanisms would likely lead to targeted new therapies with profound therapeutic implications for patients with gastrointestinal conditions. We briefly review the current state of the literature, highlighting homeostatic mechanisms important for q-ISC regulation, listing key questions in the field, and offer strategies to address them. Developmental Dynamics 245:718-726, 2016. © 2016 Wiley Periodicals, Inc. |Animals [MESH] |Homeostasis/genetics/physiology [MESH] |Humans [MESH] |Intestinal Mucosa/*metabolism [MESH] |Intestines/*cytology [MESH] |Models, Biological [MESH] |Signal Transduction [MESH] |Stem Cells/*cytology/*metabolism [MESH]An enduring role for quiescent stem cells (epmc).pdf DeepDyve Pubget Overpricing