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2017 ; 21
(7
): 531-545
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An Update on Memory Reconsolidation Updating
#MMPMID28495311
Lee JLC
; Nader K
; Schiller D
Trends Cogn Sci
2017[Jul]; 21
(7
): 531-545
PMID28495311
show ga
The reactivation of a stored memory in the brain can make the memory transiently
labile. During the time it takes for the memory to restabilize (reconsolidate)
the memory can either be reduced by an amnesic agent or enhanced by memory
enhancers. The change in memory expression is related to changes in the brain
correlates of long-term memory. Many have suggested that such retrieval-induced
plasticity is ideally placed to enable memories to be updated with new
information. This hypothesis has been tested experimentally, with a translational
perspective, by attempts to update maladaptive memories to reduce their
problematic impact. We review here progress on reconsolidation updating studies,
highlighting their translational exploitation and addressing recent challenges to
the reconsolidation field.