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10.1155/2015/962941

http://scihub22266oqcxt.onion/10.1155/2015/962941
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C4619918!4619918 !26539548
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suck abstract from ncbi


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pmid26539548
      Biomed+Res+Int 2015 ; 2015 (ä): 962941
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  • Amylose-Based Cationic Star Polymers for siRNA Delivery #MMPMID26539548
  • Nishimura T ; Umezaki K ; Mukai SA ; Sawada S ; Akiyoshi K
  • Biomed Res Int 2015[]; 2015 (ä): 962941 PMID26539548 show ga
  • A new siRNA delivery system using a cationic glyco-star polymer is described. Spermine-modified 8-arm amylose star polymer (with a degree of polymerization of approximately 60 per arm) was synthesized by chemoenzymatic methods. The cationic star polymer effectively bound to siRNA and formed spherical complexes with an average hydrodynamic diameter of 230 nm. The cationic 8-arm star polymer complexes showed superior cellular uptake characteristics and higher gene silencing effects than a cationic 1-arm polymer. These results suggest that amylose-based star polymers are a promising nanoplatform for glycobiomaterials.
  • |Amylose/*chemistry [MESH]
  • |Animals [MESH]
  • |Cations/chemistry [MESH]
  • |Cell Line, Tumor [MESH]
  • |Cell Survival/drug effects [MESH]
  • |Drug Carriers/*chemistry [MESH]
  • |Mice [MESH]
  • |Polymers/*chemistry [MESH]


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