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Amyloid precursor protein processing and bioenergetics
#MMPMID27545490
Wilkins HM
; Swerdlow RH
Brain Res Bull
2017[Jul]; 133
(?): 71-79
PMID27545490
show ga
The processing of amyloid precursor protein (APP) to amyloid beta (A?) is of
great interest to the Alzheimer's disease (AD) field. Decades of research define
how APP is altered to form A?, and how A? generates oligomers, protofibrils, and
fibrils. Numerous signaling pathways and changes in cell physiology are known to
influence APP processing. Existing data additionally indicate a relationship
exists between mitochondria, bioenergetics, and APP processing. Here, we review
data that address whether mitochondrial function and bioenergetics modify APP
processing and A? production.