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2015 ; 13
(ä): 163
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Amyloid imaging for dementia in clinical practice
#MMPMID26170121
O'Brien JT
; Herholz K
BMC Med
2015[Jul]; 13
(ä): 163
PMID26170121
show ga
In vivo imaging of brain amyloid using positron emission tomography (PET)
scanning is widely used in research studies of dementia, with three amyloid PET
ligands being licenced for clinical use. The main clinical use of PET is to help
confirm or exclude the likely diagnosis of Alzheimer's disease in challenging
cases, where diagnostic uncertainty remains after current clinical and
investigative work up. Whilst diagnostically valuable in such select cases, much
wider clinical adoption, especially for very early disease, will be limited by
both cost and the lack of a currently effective disease-modifying treatment that
requires such early case identification. The use of amyloid imaging to
appropriately stratify subjects for prognostic studies and therapeutic trials
should increase the efficiency and potentially shorten the time of such studies,
and its use combined with other biomarkers and genetics will likely lead to new
ways of defining and classifying the dementias.