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10.1016/j.semcdb.2015.08.002 http://scihub22266oqcxt.onion/10.1016/j.semcdb.2015.08.002 C4800996!4800996 !26277542     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26277542 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Semin+Cell+Dev+Biol 2015 ; 43 (ä): 22-32 Nephropedia Template TP {{tp|p=26277542 |t=2015. Amino acid management in cancer |pdf=|usr=}}{{26277542 }} gab.com Text Amino acid management in cancer JO: Semin Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=26277542 #FOAvip Amino acids have a dual role in cellular metabolism, as they are both the building blocks for protein synthesis and intermediate metabolites which fuel other biosynthetic reactions. Recent work has demonstrated that deregulation of both arms of amino acid management are common alterations seen in cancer. Among the most highly consumed nutrients by cancer cells are the amino acids glutamine and serine, and the biosynthetic pathways that metabolize them are required in various cancer subtypes and the object of current efforts to target cancer metabolism. Also altered in cancer are components of the machinery which sense amino acid sufficiency, nucleated by the mechanistic target of rapamycin (mTOR), a key regulator of cell growth via modulation of key processes including protein synthesis and autophagy. The precise ways in which altered amino acid management supports cellular transformation remain mostly elusive, and a fuller mechanistic understanding of these processes will be important for efforts to exploit such alterations for cancer therapy. Twit Text FOAVip Amino acid management in cancer ????Semin Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=26277542 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26277542 #FOAvip English Wikipedia <ref>{{Cite pmid|26277542 }}</ref> Amino acid management in cancer #MMPMID26277542 Tsun ZY ; Possemato R Semin Cell Dev Biol 2015[Jul]; 43 (ä): 22-32 PMID26277542 show ga Amino acids have a dual role in cellular metabolism, as they are both the building blocks for protein synthesis and intermediate metabolites which fuel other biosynthetic reactions. Recent work has demonstrated that deregulation of both arms of amino acid management are common alterations seen in cancer. Among the most highly consumed nutrients by cancer cells are the amino acids glutamine and serine, and the biosynthetic pathways that metabolize them are required in various cancer subtypes and the object of current efforts to target cancer metabolism. Also altered in cancer are components of the machinery which sense amino acid sufficiency, nucleated by the mechanistic target of rapamycin (mTOR), a key regulator of cell growth via modulation of key processes including protein synthesis and autophagy. The precise ways in which altered amino acid management supports cellular transformation remain mostly elusive, and a fuller mechanistic understanding of these processes will be important for efforts to exploit such alterations for cancer therapy. |Citric Acid Cycle/*physiology [MESH] |Glutamine/*metabolism [MESH] |Humans [MESH] |Neoplasms/*pathology [MESH] |Protein Biosynthesis/*physiology [MESH] |Serine/*metabolism [MESH] |Signal Transduction/physiology [MESH]Amino acid management in cancer (epmc).pdf DeepDyve Pubget Overpricing