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2015 ; 7
(Suppl 2
): 19-24
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Ameloblastoma: A Review of Recent Molecular Pathogenetic Discoveries
#MMPMID26483612
Brown NA
; Betz BL
Biomark Cancer
2015[]; 7
(Suppl 2
): 19-24
PMID26483612
show ga
Ameloblastoma is an odontogenic neoplasm whose molecular pathogenesis has only
recently been elucidated. The discovery of recurrent activating mutations in
FGFR2, BRAF, and RAS in a large majority of ameloblastomas has implicated
dysregulation of MAPK pathway signaling as a critical step in the pathogenesis of
this tumor. Some degree of controversy exists regarding the role of mutations
affecting the sonic hedgehog (SHH) pathway, specifically Smoothened (SMO), which
have been postulated to serve as either an alternative pathogenetic mechanism or
secondary mutations. Here, we review recent advances in our understanding of the
molecular pathogenesis of ameloblastoma as well as the diagnostic, prognostic,
and therapeutic implications of these discoveries.