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10.1038/nrm.2016.116 http://scihub22266oqcxt.onion/10.1038/nrm.2016.116 C5483950!5483950 !27677860     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27677860 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Rev+Mol+Cell+Biol 2017 ; 18 (1 ): 18-30 Nephropedia Template TP {{tp|p=27677860 |t=2017. Alternative polyadenylation of mRNA precursors |pdf=|usr=}}{{27677860 }} gab.com Text Alternative polyadenylation of mRNA precursors JO: Nat Rev Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27677860 #FOAvip Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct 3' termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all eukaryotic species and is recognized as a major mechanism of gene regulation. APA exhibits tissue specificity and is important for cell proliferation and differentiation. In this Review, we discuss the roles of APA in diverse cellular processes, including mRNA metabolism, protein diversification and protein localization, and more generally in gene regulation. We also discuss the molecular mechanisms underlying APA, such as variation in the concentration of core processing factors and RNA-binding proteins, as well as transcription-based regulation. Twit Text FOAVip Alternative polyadenylation of mRNA precursors ????Nat Rev Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27677860 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27677860 #FOAvip English Wikipedia <ref>{{Cite pmid|27677860 }}</ref> Alternative polyadenylation of mRNA precursors #MMPMID27677860 Tian B ; Manley JL Nat Rev Mol Cell Biol 2017[Jan]; 18 (1 ): 18-30 PMID27677860 show ga Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct 3' termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all eukaryotic species and is recognized as a major mechanism of gene regulation. APA exhibits tissue specificity and is important for cell proliferation and differentiation. In this Review, we discuss the roles of APA in diverse cellular processes, including mRNA metabolism, protein diversification and protein localization, and more generally in gene regulation. We also discuss the molecular mechanisms underlying APA, such as variation in the concentration of core processing factors and RNA-binding proteins, as well as transcription-based regulation. |*3' Untranslated Regions [MESH] |*Polyadenylation [MESH] |Active Transport, Cell Nucleus [MESH] |Exons [MESH] |Gene Expression Regulation [MESH] |Humans [MESH] |RNA Precursors/genetics/*metabolism [MESH] |RNA Stability [MESH] |RNA, Messenger/genetics/*metabolism [MESH] |RNA-Binding Proteins/metabolism [MESH]Alternative polyadenylation of mRNA precursors (epmc).pdf DeepDyve Pubget Overpricing