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Altered network hub connectivity after acute LSD administration
#MMPMID29560311
Müller F
; Dolder PC
; Schmidt A
; Liechti ME
; Borgwardt S
Neuroimage Clin
2018[]; 18
(?): 694-701
PMID29560311
show ga
LSD is an ambiguous substance, said to mimic psychosis and to improve mental
health in people suffering from anxiety and depression. Little is known about the
neuronal correlates of altered states of consciousness induced by this substance.
Limited previous studies indicated profound changes in functional connectivity of
resting state networks after the administration of LSD. The current investigation
attempts to replicate and extend those findings in an independent sample. In a
double-blind, randomized, cross-over study, 100??g LSD and placebo were orally
administered to 20 healthy participants. Resting state brain activity was
assessed by functional magnetic resonance imaging. Within-network and
between-network connectivity measures of ten established resting state networks
were compared between drug conditions. Complementary analysis were conducted
using resting state networks as sources in seed-to-voxel analyses. Acute LSD
administration significantly decreased functional connectivity within visual,
sensorimotor and auditory networks and the default mode network. While
between-network connectivity was widely increased and all investigated networks
were affected to some extent, seed-to-voxel analyses consistently indicated
increased connectivity between networks and subcortical (thalamus, striatum) and
cortical (precuneus, anterior cingulate cortex) hub structures. These latter
observations are consistent with findings on the importance of hubs in
psychopathological states, especially in psychosis, and could underlay
therapeutic effects of hallucinogens as proposed by a recent model.
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