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2017 ; 7
(ä): 381
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Alterations of the Gut Microbiome in Hypertension
#MMPMID28884091
Yan Q
; Gu Y
; Li X
; Yang W
; Jia L
; Chen C
; Han X
; Huang Y
; Zhao L
; Li P
; Fang Z
; Zhou J
; Guan X
; Ding Y
; Wang S
; Khan M
; Xin Y
; Li S
; Ma Y
Front Cell Infect Microbiol
2017[]; 7
(ä): 381
PMID28884091
show ga
Introduction: Human gut microbiota is believed to be directly or indirectly
involved in cardiovascular diseases and hypertension. However, the identification
and functional status of the hypertension-related gut microbe(s) have not yet
been surveyed in a comprehensive manner. Methods: Here we characterized the gut
microbiome in hypertension status by comparing fecal samples of 60 patients with
primary hypertension and 60 gender-, age-, and body weight-matched healthy
controls based on whole-metagenome shotgun sequencing. Results: Hypertension
implicated a remarkable gut dysbiosis with significant reduction in within-sample
diversity and shift in microbial composition. Metagenome-wide association study
(MGWAS) revealed 53,953 microbial genes that differ in distribution between the
patients and healthy controls (false discovery rate, 0.05) and can be grouped
into 68 clusters representing bacterial species. Opportunistic pathogenic taxa,
such as, Klebsiella spp., Streptococcus spp., and Parabacteroides merdae were
frequently distributed in hypertensive gut microbiome, whereas the short-chain
fatty acid producer, such as, Roseburia spp. and Faecalibacterium prausnitzii,
were higher in controls. The number of hypertension-associated species also
showed stronger correlation to the severity of disease. Functionally, the
hypertensive gut microbiome exhibited higher membrane transport,
lipopolysaccharide biosynthesis and steroid degradation, while in controls the
metabolism of amino acid, cofactors and vitamins was found to be higher. We
further provided the microbial markers for disease discrimination and achieved an
area under the receiver operator characteristic curve (AUC) of 0.78,
demonstrating the potential of gut microbiota in prediction of hypertension.
Conclusion: These findings represent specific alterations in microbial diversity,
genes, species and functions of the hypertensive gut microbiome. Further studies
on the causality relationship between hypertension and gut microbiota will offer
new prospects for treating and preventing the hypertension and its associated
diseases.
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