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2016 ; 21
(ä): 29
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Alpha-synuclein structure, functions, and interactions
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Emamzadeh FN
J Res Med Sci
2016[]; 21
(ä): 29
PMID27904575
show ga
At present, when a clinical diagnosis of Parkinson's disease (PD) is made,
serious damage has already been done to nerve cells of the substantia nigra pars
compacta. The diagnosis of PD in its earlier stages, before this irreversible
damage, would be of enormous benefit for future treatment strategies designed to
slow or halt the progression of this disease that possibly prevents accumulation
of toxic aggregates. As a molecular biomarker for the detection of PD in its
earlier stages, alpha-synuclein (?-syn), which is a key component of Lewy bodies,
in which it is found in an aggregated and fibrillar form, has attracted
considerable attention. Here, ?-syn is reviewed in details.