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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Endocrinol+Invest
2014 ; 37
(11
): 1121-6
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Alpha Klotho and phosphate homeostasis
#MMPMID25194425
Bian A
; Xing C
; Hu MC
J Endocrinol Invest
2014[Nov]; 37
(11
): 1121-6
PMID25194425
show ga
The Klotho family consists of three single-pass transmembrane proteins??Klotho,
?Klotho and ?Klotho. Each of them combines with fibroblast growth factor (FGF)
receptors (FGFRs) to form receptor complexes for various FGF?s. ?Klotho is a
co-receptor for physiological FGF23 signaling and appears essential for
FGF23-mediated regulation of mineral metabolism. ?Klotho protein also plays a
FGF23-independent role in phosphate homeostasis. Animal experimental studies and
clinical observations have demonstrated that ?Klotho deficiency leads to severe
hyperphosphatemia; moderate elevation of ?Klotho reduces serum phosphate and
extremely high ?Klotho induces hypophosphatemia and high-FGF23. ?Klotho maintains
circulating phosphate in a narrow range by modulating intestinal phosphate
absorption, urinary phosphate excretion by the kidney, and phosphate distribution
into bone rather than soft tissue in concerted interaction with other
calciophosphotropic hormones such as PTH, FGF23, and 1,25-(OH)(2) vitamin D. The
role of ?Klotho in maintenance of phosphate homeostasis is mediated by direct
suppression of Na-dependent phosphate cotransporters in target organs. Therefore,
?Klotho manipulation may be a novel strategy for genetic and acquired phosphate
disorders and for medical conditions with ?Klotho deficiency such as chronic
kidney disease in future.
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