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2014 ; 7
(3
): a016352
Nephropedia Template TP
Cold Spring Harb Perspect Biol
2014[Nov]; 7
(3
): a016352
PMID25414367
show ga
Allergic inflammation is associated closely with parasite infection but also
asthma and other common allergic diseases. Despite the engagement of similar
immunologic pathways, parasitized individuals often show no outward
manifestations of allergic disease. In this perspective, we present the thesis
that allergic inflammatory responses play a primary role in regulating circadian
and environmental inputs involved with tissue homeostasis and metabolic needs.
Parasites feed into these pathways and thus engage allergic inflammation to
sustain aspects of the parasitic life cycle. In response to parasite infection,
an adaptive and regulated immune response is layered on the host effector
response, but in the setting of allergy, the effector response remains
unregulated, thus leading to the cardinal features of disease. Further
understanding of the homeostatic pressures driving allergic inflammation holds
promise to further our understanding of human health and the treatment of these
common afflictions.
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