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2016 ; 8
(3
): 191-7
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Allergen Immunotherapy: Past, Present, and Future
#MMPMID26922928
Jutel M
; Kosowska A
; Smolinska S
Allergy Asthma Immunol Res
2016[May]; 8
(3
): 191-7
PMID26922928
show ga
Allergen-specific immunotherapy (AIT), although in clinical use for more than a
century, is still the only causal treatment of allergic diseases. The safety and
efficacy of AIT has been demonstrated in a large number of clinical trials. In
addition to allergy symptom reduction AIT plays an essential role in preventing
new allergies and asthma and shows long-term effects after discontinuation of
treatment. Ideally, it is capable of curing allergy. However, AIT is not
effective in all allergic individuals and is not equally effective in the
treatment of various hypersensitivities to different allergens. For many years,
the route of administration and the vaccine compositions have been evolving.
Still there is a strong need for research in the field of new AIT modalities to
increase its effectiveness and safety. Growing evidence on immunological effects
of AIT, especially new T cell subsets involved in antigen/allergen tolerance,
provides novel concepts for safer and more effective vaccination.
Pharmacoeconomic studies have demonstrated a clear advantage of AIT over
pharmacologic therapies.
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