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2014 ; 14
(4
): 291-308
Nephropedia Template TP
Cardiovasc Toxicol
2014[Dec]; 14
(4
): 291-308
PMID24671642
show ga
Alcoholic cardiomyopathy (ACM) is a specific heart muscle disease found in
individuals with a history of long-term heavy alcohol consumption. ACM is
associated with a number of adverse histological, cellular, and structural
changes within the myocardium. Several mechanisms are implicated in mediating the
adverse effects of ethanol, including the generation of oxidative stress,
apoptotic cell death, impaired mitochondrial bioenergetics/stress, derangements
in fatty acid metabolism and transport, and accelerated protein catabolism. In
this review, we discuss the evidence for such mechanisms and present the
potential importance of drinking patterns, genetic susceptibility, nutritional
factors, race, and sex. The purpose of this review is to provide a mechanistic
paradigm for future research in the area of ACM.
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