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10.3390/biom5032023 http://scihub22266oqcxt.onion/10.3390/biom5032023 C4598786!4598786 !26343741     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26343741 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26343741 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biomolecules 2015 ; 5 (3 ): 2023-34 Nephropedia Template TP {{tp|p=26343741 |t=2015. Alcoholic Liver Disease: Role of Cytokines |pdf=|usr=}}{{26343741 }} gab.com Text Alcoholic Liver Disease: Role of Cytokines JO: Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=26343741 #FOAvip The present review spans a broad spectrum of topics dealing with alcoholic liver disease (ALD), including clinical and translational research. It focuses on the role of the immune system and the signaling pathways of cytokines in the pathogenesis of ALD. An additional factor that contributes to the pathogenesis of ALD is lipopolysaccharide (LPS), which plays a central role in the induction of steatosis, inflammation, and fibrosis in the liver. LPS derived from the intestinal microbiota enters the portal circulation, and is recognized by macrophages (Kupffer cells) and hepatocytes. In individuals with ALD, excessive levels of LPS in the liver affect immune, parenchymal, and non-immune cells, which in turn release various inflammatory cytokines and recruit neutrophils and other inflammatory cells. In this review, we elucidate the mechanisms by which alcohol contributes to the activation of Kupffer cells and the inflammatory cascade. The role of the stellate cells in fibrogenesis is also discussed. Twit Text FOAVip Alcoholic Liver Disease: Role of Cytokines ????Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=26343741 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26343741 #FOAvip English Wikipedia <ref>{{Cite pmid|26343741 }}</ref> Alcoholic Liver Disease: Role of Cytokines #MMPMID26343741 Neuman MG ; Maor Y ; Nanau RM ; Melzer E ; Mell H ; Opris M ; Cohen L ; Malnick S Biomolecules 2015[Aug]; 5 (3 ): 2023-34 PMID26343741 show ga The present review spans a broad spectrum of topics dealing with alcoholic liver disease (ALD), including clinical and translational research. It focuses on the role of the immune system and the signaling pathways of cytokines in the pathogenesis of ALD. An additional factor that contributes to the pathogenesis of ALD is lipopolysaccharide (LPS), which plays a central role in the induction of steatosis, inflammation, and fibrosis in the liver. LPS derived from the intestinal microbiota enters the portal circulation, and is recognized by macrophages (Kupffer cells) and hepatocytes. In individuals with ALD, excessive levels of LPS in the liver affect immune, parenchymal, and non-immune cells, which in turn release various inflammatory cytokines and recruit neutrophils and other inflammatory cells. In this review, we elucidate the mechanisms by which alcohol contributes to the activation of Kupffer cells and the inflammatory cascade. The role of the stellate cells in fibrogenesis is also discussed. |Alcoholism/metabolism [MESH] |Cytokines/*metabolism [MESH] |Humans [MESH] |Lipopolysaccharides/metabolism [MESH]Alcoholic Liver Disease: Role of Cytokines (epmc).pdf DeepDyve Pubget Overpricing