Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1164/rccm.201408-1492PP http://scihub22266oqcxt.onion/10.1164/rccm.201408-1492PP C4299651!4299651 !25354273     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25354273 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Respir+Crit+Care+Med 2014 ; 190 (12 ): 1355-62 Nephropedia Template TP {{tp|p=25354273 |t=2014. Airway basal cells The "smoking gun" of chronic obstructive pulmonary disease |pdf=|usr=}}{{25354273 }} gab.com Text Airway basal cells The "smoking gun" of chronic obstructive pulmonary disease JO: Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=25354273 #FOAvip The earliest abnormality in the lung associated with smoking is hyperplasia of airway basal cells, the stem/progenitor cells of the ciliated and secretory cells that are central to pulmonary host defense. Using cell biology and 'omics technologies to assess basal cells isolated from bronchoscopic brushings of nonsmokers, smokers, and smokers with chronic obstructive pulmonary disease (COPD), compelling evidence has been provided in support of the concept that airway basal cells are central to the pathogenesis of smoking-associated lung diseases. When confronted by the chronic stress of smoking, airway basal cells become disorderly, regress to a more primitive state, behave as dictated by their inheritance, are susceptible to acquired changes in their genome, lose the capacity to regenerate the epithelium, are responsible for the major changes in the airway that characterize COPD, and, with persistent stress, can undergo malignant transformation. Together, these observations led to the conclusion that accelerated loss of lung function in susceptible individuals begins with disordered airway basal cell biology (i.e., that airway basal cells are the "smoking gun" of COPD, a potential target for the development of therapies to prevent smoking-related lung disorders). Twit Text FOAVip Airway basal cells The "smoking gun" of chronic obstructive pulmonary disease ????Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=25354273 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25354273 #FOAvip English Wikipedia <ref>{{Cite pmid|25354273 }}</ref> Airway basal cells The "smoking gun" of chronic obstructive pulmonary disease #MMPMID25354273 Crystal RG Am J Respir Crit Care Med 2014[Dec]; 190 (12 ): 1355-62 PMID25354273 show ga The earliest abnormality in the lung associated with smoking is hyperplasia of airway basal cells, the stem/progenitor cells of the ciliated and secretory cells that are central to pulmonary host defense. Using cell biology and 'omics technologies to assess basal cells isolated from bronchoscopic brushings of nonsmokers, smokers, and smokers with chronic obstructive pulmonary disease (COPD), compelling evidence has been provided in support of the concept that airway basal cells are central to the pathogenesis of smoking-associated lung diseases. When confronted by the chronic stress of smoking, airway basal cells become disorderly, regress to a more primitive state, behave as dictated by their inheritance, are susceptible to acquired changes in their genome, lose the capacity to regenerate the epithelium, are responsible for the major changes in the airway that characterize COPD, and, with persistent stress, can undergo malignant transformation. Together, these observations led to the conclusion that accelerated loss of lung function in susceptible individuals begins with disordered airway basal cell biology (i.e., that airway basal cells are the "smoking gun" of COPD, a potential target for the development of therapies to prevent smoking-related lung disorders). |Humans [MESH] |Lung Neoplasms/etiology/pathology [MESH] |Lung/cytology/pathology [MESH] |Pulmonary Disease, Chronic Obstructive/*etiology/pathology [MESH] |Respiratory Mucosa/cytology/pathology [MESH] |Smoking/adverse effects/pathology [MESH]Airway basal cells The "smoking gun" of chronic obstructive pulmonary(epmc).pdf DeepDyve Pubget Overpricing