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10.3389/fphys.2015.00346 http://scihub22266oqcxt.onion/10.3389/fphys.2015.00346 C4667091!4667091 !26696894     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26696894 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Front+Physiol 2015 ; 6 (ä): 346 Nephropedia Template TP {{tp|p=26696894 |t=2015. Airway and Extracellular Matrix Mechanics in COPD |pdf=|usr=}}{{26696894 }} gab.com Text Airway and Extracellular Matrix Mechanics in COPD JO: Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26696894 #FOAvip Chronic obstructive pulmonary disease (COPD) is one of the most common lung diseases worldwide, and is characterized by airflow obstruction that is not fully reversible with treatment. Even though airflow obstruction is caused by airway smooth muscle contraction, the extent of airway narrowing depends on a range of other structural and functional determinants that impact on active and passive tissue mechanics. Cells and extracellular matrix in the airway and parenchymal compartments respond both passively and actively to the mechanical stimulation induced by smooth muscle contraction. In this review, we summarize the factors that regulate airway narrowing and provide insight into the relative contributions of different constituents of the extracellular matrix and their biomechanical impact on airway obstruction. We then review the changes in extracellular matrix composition in the airway and parenchymal compartments at different stages of COPD, and finally discuss how these changes impact airway narrowing and the development of airway hyperresponsiveness. Finally, we position these data in the context of therapeutic research focused on defective tissue repair. As a conclusion, we propose that future works should primarily target mild or early COPD, prior to the widespread structural changes in the alveolar compartment that are more characteristic of severe COPD. Twit Text FOAVip Airway and Extracellular Matrix Mechanics in COPD ????Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26696894 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26696894 #FOAvip English Wikipedia <ref>{{Cite pmid|26696894 }}</ref> Airway and Extracellular Matrix Mechanics in COPD #MMPMID26696894 Bidan CM ; Veldsink AC ; Meurs H ; Gosens R Front Physiol 2015[]; 6 (ä): 346 PMID26696894 show ga Chronic obstructive pulmonary disease (COPD) is one of the most common lung diseases worldwide, and is characterized by airflow obstruction that is not fully reversible with treatment. Even though airflow obstruction is caused by airway smooth muscle contraction, the extent of airway narrowing depends on a range of other structural and functional determinants that impact on active and passive tissue mechanics. Cells and extracellular matrix in the airway and parenchymal compartments respond both passively and actively to the mechanical stimulation induced by smooth muscle contraction. In this review, we summarize the factors that regulate airway narrowing and provide insight into the relative contributions of different constituents of the extracellular matrix and their biomechanical impact on airway obstruction. We then review the changes in extracellular matrix composition in the airway and parenchymal compartments at different stages of COPD, and finally discuss how these changes impact airway narrowing and the development of airway hyperresponsiveness. Finally, we position these data in the context of therapeutic research focused on defective tissue repair. As a conclusion, we propose that future works should primarily target mild or early COPD, prior to the widespread structural changes in the alveolar compartment that are more characteristic of severe COPD. äAirway and Extracellular Matrix Mechanics in COPD (epmc).pdf DeepDyve Pubget Overpricing