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10.1080/07924259.2014.938197 http://scihub22266oqcxt.onion/10.1080/07924259.2014.938197 C4463770!4463770 !26136620     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26136620 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26136620 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Invertebr+Reprod+Dev 2015 ; 59 (sup1 ): 45-50 Nephropedia Template TP {{tp|p=26136620 |t=2015. Aging in the colonial chordate, Botryllus schlosseri |pdf=|usr=}}{{26136620 }} gab.com Text Aging in the colonial chordate, Botryllus schlosseri JO: Invertebr Reprod Dev http://www.kidney.de/pget.php?&tw=1&pmid=26136620 #FOAvip What mechanisms underlie aging? One theory, the wear-and-tear model, attributes aging to progressive deterioration in the molecular and cellular machinery which eventually lead to death through the disruption of physiological homeostasis. The second suggests that life span is genetically programmed, and aging may be derived from intrinsic processes which enforce a non-random, terminal time interval for the survivability of the organism. We are studying an organism that demonstrates both properties: the colonial ascidian, Botryllus schlosseri. Botryllus is a member of the Tunicata, the sister group to the vertebrates, and has a number of life history traits which make it an excellent model for studies on aging. First, Botryllus has a colonial life history, and grows by a process of asexual reproduction during which entire bodies, including all somatic and germline lineages, regenerate every week, resulting in a colony of genetically identical individuals. Second, previous studies of lifespan in genetically distinct Botryllus lineages suggest that a direct, heritable basis underlying mortality exists that is unlinked to reproductive effort and other life history traits. Here we will review recent efforts to take advantage of the unique life history traits of B. schlosseri and develop it into a robust model for aging research. Twit Text FOAVip Aging in the colonial chordate, Botryllus schlosseri ????Invertebr Reprod Dev http://www.kidney.de/pget.php?&tw=1&pmid=26136620 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26136620 #FOAvip English Wikipedia <ref>{{Cite pmid|26136620 }}</ref> Aging in the colonial chordate, Botryllus schlosseri #MMPMID26136620 Munday R ; Rodriguez D ; Di Maio A ; Kassmer S ; Braden B ; Taketa DA ; Langenbacher A ; De Tomaso A Invertebr Reprod Dev 2015[Jan]; 59 (sup1 ): 45-50 PMID26136620 show ga What mechanisms underlie aging? One theory, the wear-and-tear model, attributes aging to progressive deterioration in the molecular and cellular machinery which eventually lead to death through the disruption of physiological homeostasis. The second suggests that life span is genetically programmed, and aging may be derived from intrinsic processes which enforce a non-random, terminal time interval for the survivability of the organism. We are studying an organism that demonstrates both properties: the colonial ascidian, Botryllus schlosseri. Botryllus is a member of the Tunicata, the sister group to the vertebrates, and has a number of life history traits which make it an excellent model for studies on aging. First, Botryllus has a colonial life history, and grows by a process of asexual reproduction during which entire bodies, including all somatic and germline lineages, regenerate every week, resulting in a colony of genetically identical individuals. Second, previous studies of lifespan in genetically distinct Botryllus lineages suggest that a direct, heritable basis underlying mortality exists that is unlinked to reproductive effort and other life history traits. Here we will review recent efforts to take advantage of the unique life history traits of B. schlosseri and develop it into a robust model for aging research. äAging in the colonial chordate, Botryllus schlosseri (epmc).pdf DeepDyve Pubget Overpricing