Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29081695
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29081695
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Genomics
2017 ; 18
(5
): 385-407
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Aging as an Epigenetic Phenomenon
#MMPMID29081695
Ashapkin VV
; Kutueva LI
; Vanyushin BF
Curr Genomics
2017[Oct]; 18
(5
): 385-407
PMID29081695
show ga
INTRODUCTION: Hypermethylation of genes associated with promoter CpG islands, and
hypomethylation of CpG poor genes, repeat sequences, transposable elements and
intergenic genome sections occur during aging in mammals. Methylation levels of
certain CpG sites display strict correlation to age and could be used as
"epigenetic clock" to predict biological age. Multi-substrate deacetylases SIRT1
and SIRT6 affect aging via locus-specific modulations of chromatin structure and
activity of multiple regulatory proteins involved in aging. Random errors in DNA
methylation and other epigenetic marks during aging increase the transcriptional
noise, and thus lead to enhanced phenotypic variation between cells of the same
tissue. Such variation could cause progressive organ dysfunction observed in aged
individuals. Multiple experimental data show that induction of NF-?B regulated
gene sets occurs in various tissues of aged mammals. Upregulation of multiple
miRNAs occurs at mid age leading to downregulation of enzymes and regulatory
proteins involved in basic cellular functions, such as DNA repair, oxidative
phosphorylation, intermediate metabolism, and others. CONCLUSION: Strong evidence
shows that all epigenetic systems contribute to the lifespan control in various
organisms. Similar to other cell systems, epigenome is prone to gradual
degradation due to the genome damage, stressful agents, and other aging factors.
But unlike mutations and other kinds of the genome damage, age-related epigenetic
changes could be fully or partially reversed to a "young" state.
free
free
free
