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10.1189/jlb.0805456 http://scihub22266oqcxt.onion/10.1189/jlb.0805456 C4482138!4482138 !16543402     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\16543402 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Leukoc+Biol 2006 ; 79 (6 ): 1242-51 Nephropedia Template TP {{tp|p=16543402 |t=2006. Aggregated IgG inhibits the differentiation of human fibrocytes |pdf=|usr=}}{{16543402 }} gab.com Text Aggregated IgG inhibits the differentiation of human fibrocytes JO: J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=16543402 #FOAvip Fibrocytes are fibroblast-like cells, which appear to participate in wound healing and are present in pathological lesions associated with asthma, pulmonary fibrosis, and scleroderma. Fibrocytes differentiate from CD14+ peripheral blood monocytes, and the presence of serum delays this process dramatically. We previously purified the factor in serum, which inhibits fibrocyte differentiation, and identified it as serum amyloid P (SAP). As SAP binds to Fc receptors for immunoglobulin G (IgG; Fc gammaRs), Fc gammaR activation may be an inhibitory signal for fibrocyte differentiation. Fc gammaR are activated by aggregated IgG, and we find aggregated but not monomeric, human IgG inhibits human fibrocyte differentiation. Monoclonal antibodies that bind to Fc gammaRI (CD64) or Fc gammaRII (CD32) also inhibit fibrocyte differentiation. Aggregated IgG lacking Fc domains or aggregated IgA, IgE, or IgM do not inhibit fibrocyte differentiation. Incubation of monocytes with SAP or aggregated IgG inhibited fibrocyte differentiation. Using inhibitors of protein kinase enzymes, we show that Syk- and Src-related tyrosine kinases participate in the inhibition of fibrocyte differentiation. These observations suggest that fibrocyte differentiation can occur in situations where SAP and aggregated IgG levels are low, such as the resolution phase of inflammation. Twit Text FOAVip Aggregated IgG inhibits the differentiation of human fibrocytes ????J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=16543402 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=16543402 #FOAvip English Wikipedia <ref>{{Cite pmid|16543402 }}</ref> Aggregated IgG inhibits the differentiation of human fibrocytes #MMPMID16543402 Pilling D ; Tucker NM ; Gomer RH J Leukoc Biol 2006[Jun]; 79 (6 ): 1242-51 PMID16543402 show ga Fibrocytes are fibroblast-like cells, which appear to participate in wound healing and are present in pathological lesions associated with asthma, pulmonary fibrosis, and scleroderma. Fibrocytes differentiate from CD14+ peripheral blood monocytes, and the presence of serum delays this process dramatically. We previously purified the factor in serum, which inhibits fibrocyte differentiation, and identified it as serum amyloid P (SAP). As SAP binds to Fc receptors for immunoglobulin G (IgG; Fc gammaRs), Fc gammaR activation may be an inhibitory signal for fibrocyte differentiation. Fc gammaR are activated by aggregated IgG, and we find aggregated but not monomeric, human IgG inhibits human fibrocyte differentiation. Monoclonal antibodies that bind to Fc gammaRI (CD64) or Fc gammaRII (CD32) also inhibit fibrocyte differentiation. Aggregated IgG lacking Fc domains or aggregated IgA, IgE, or IgM do not inhibit fibrocyte differentiation. Incubation of monocytes with SAP or aggregated IgG inhibited fibrocyte differentiation. Using inhibitors of protein kinase enzymes, we show that Syk- and Src-related tyrosine kinases participate in the inhibition of fibrocyte differentiation. These observations suggest that fibrocyte differentiation can occur in situations where SAP and aggregated IgG levels are low, such as the resolution phase of inflammation. |Antibodies, Monoclonal/pharmacology [MESH] |Biopolymers/pharmacology [MESH] |Cell Differentiation/drug effects [MESH] |Cells, Cultured/cytology/drug effects [MESH] |Fibroblasts/cytology/*drug effects [MESH] |Humans [MESH] |Immunoglobulin A/immunology/pharmacology [MESH] |Immunoglobulin E/immunology/pharmacology [MESH] |Immunoglobulin Fc Fragments/immunology [MESH] |Immunoglobulin G/immunology/*pharmacology [MESH] |Immunoglobulin M/immunology/pharmacology [MESH] |Intracellular Signaling Peptides and Proteins/antagonists & inhibitors/physiology [MESH] |Monocytes/cytology/*drug effects [MESH] |Phosphorylation [MESH] |Protein Processing, Post-Translational [MESH] |Protein-Tyrosine Kinases/antagonists & inhibitors/*physiology [MESH] |Receptors, IgG/antagonists & inhibitors/immunology/physiology [MESH] |Serum Amyloid P-Component/physiology [MESH] |Syk Kinase [MESH]Aggregated IgG inhibits the differentiation of human fibrocytes (epmc).pdf DeepDyve Pubget Overpricing