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2015 ; 370
(1676
): ä Nephropedia Template TP
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Ageing of the B-cell repertoire
#MMPMID26194751
Martin V
; Bryan Wu YC
; Kipling D
; Dunn-Walters D
Philos Trans R Soc Lond B Biol Sci
2015[Sep]; 370
(1676
): ä PMID26194751
show ga
Older people are more susceptible to infection, less responsive to vaccination
and have a more inflammatory immune environment. Using spectratype analysis, we
have previously shown that the B-cell repertoire of older people shows evidence
of inappropriate clonal expansions in the absence of challenge, and that this
loss of B-cell diversity correlates with poor health. Studies on response to
vaccination, using both spectratyping and high-throughput sequencing of the
repertoire, indicate that older responses to challenge are lacking in magnitude
and/or delayed significantly. Also that some of the biologically significant
differences may be in different classes of antibody. We have also previously
shown that normal young B-cell repertoires can vary between different phenotypic
subsets of B cells. In this paper, we present an analysis of immunoglobulin
repertoire in different subclasses of antibody in five different populations of B
cell, and show how the repertoire in these different groups changes with age.
Although some age-related repertoire differences occur in naive cells, before
exogenous antigen exposure, we see indications that there is a general
dysregulation of the selective forces that shape memory B-cell populations in
older people.
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